Protein-free Medium Gauges Demand to Overcome Challenges in COVID-19 Vaccine Production
With many around the world affected by the COVID-19, pharmaceutical companies are boosting their production capabilities to develop vaccines. Such trends are creating revenue opportunities for players in the serum-free media market. Lonza Group – a Swiss multinational chemicals and biotechnology company, is gaining recognition for its ProVeroTM1 Serum-free Medium, which is of non-animal origin and supports vaccine production.
Companies in the serum-free media market are taking cues from such innovations and increasing the availability of protein-free medium, which is optimized for fast cell proliferation. They are developing several serum-free media (SFM) options that help to reduce production variables for vaccine production. In order to avoid any challenges during the downstream processing of recombinant protein or vaccine production, manufacturers are opting for protein-free medium.
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Low Levels of Human Recombinant Insulin in Media Facilitates Downstream Processing
The global serum-free media market is projected to reach US$ 660.4 Mn by 2031. Manufacturers are increasing their output capacities in customized cell culture media. Thermo Fisher Scientific – the U.S. provisioner of scientific instrumentation, reagents & consumables, and software services, is publicizing its Gibco serum-free media, which promotes superior cell growth and viability.
Manufacturers in the serum-free media market are developing medium that enable precise evaluations of cellular function and facilitate consistent performance. Enhanced detection of cellular mediators and for better control over physiological responsiveness is preferred in serum-free media. The absence of proteins and only very low levels of human recombinant insulin facilitate both downstream processing and regulatory compliance.
Key Components of SFM Optimized to Develop Recombinant Therapeutic Proteins
The increasing demand for recombinant protein products is fueling the production of serum-free media. The serum-free media market is expected to advance at a favorable CAGR of 7% during the forecast tenure. Different media contain different formulations that have the potential to adapt to the growth of different cell lines and the production of recombinant protein.
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Based on the characteristics of Chinese hamster ovary (CHO) cells and its advantages in recombinant therapeutic protein (RTP) production, key components of SFM are being optimized to different degrees and proportions. The Plackett Burman method (PBM) and the response surface method are routinely used for SFM optimization and can be combined with other statistical methods such as non-parametric Gaussian kernel regression.
FBS-free Medium Eliminates Possibility of Lot Variations in MSCs During Manufacture
Mesenchymal Stem/Stromal Cells (MSCs) hold promising potentials for treating a variety of conditions in veterinary medicine. MSCs are isolated and expanded invitro in a medium that is supplemented with fetal bovine serum (FBS). However, the use of FBS as a medium component during manufacturing may pose several issues. Since FBS can be a source of unwanted pathogens, companies in the serum-free media market are partnering with researchers to develop FBS-free medium that supports both isolation and expansion of MSCs from canine adipose tissue, while removing unwanted pathogens, immune response, and lot-to-lot variations.
Serum-free Hybridoma Helps Prevent Contamination of Cell Culture Facilities
Companies in the serum-free media market are boosting the production of hybridoma media. Leinco Technologies – a biotechnology company in Fenton, Missouri, is gaining popularity for its AlphaGrow Serum Free Hybridoma that offers better lot-to-lot consistency in applications. Increased antibody production and low cost attributes of serum-free hybridoma are being preferred by researchers and scientists.
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The inconveniences of serum include the need to screen lots and is subject to variability in cost & quality. Companies are capitalizing on this opportunity, since the presence of contaminating bovine IgG creates issues for researchers. Such findings are triggering the demand for serum-free hybridoma media, as animal-derived ingredients carry the risk of introducing adventitious agents such as viruses and prions that can contaminate cell culture facilities.
Serum-free Cell Culturing Gaining Prominence in Biological Facilities
Apart from CHO cell media and protein expression media, companies in the serum-free media market are increasing their focus on human microglial cell culture serum-free media. On the other hand, serum-free cell culturing is gaining recognition in biological facilities. Researchers in cell biology are familiar with adding bovine or calf serum to cell cultures. Unfortunately, adding serum means adding a highly variable and non-standardized product to a well ordered system. Hence, manufacturers are leveraging this opportunity to boost product innovations.
Companies are increasing the availability of chemically defined serum-free media. Serum-free cell culturing is gaining market prominence, since objections have been raised to the use of serum in cell culture on regulatory and ethical grounds.
Serum-free Media Market: Overview
- According to Transparency Market Research’s latest research report on the global serum-free media market for the historical period 2017–2019 and the forecast period 2021–2031, easier downstream processing of products after production from media and increase in demand for various recombinant proteins & types of culture are projected to drive the global serum-free media market during the forecast period
- According to the report, the global serum-free media market was valued at US$ 320 Mn in 2020 and is anticipated to expand at a CAGR of 7% from 2021 to 2031
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Easier Downstream Processing of Products Post Production from Media
- Concentration of proteins in serum media is generally higher than proteins produced by mammalian cells in vivo, which makes separation of target molecule difficult
- Serum proteins in cell culture media are significant contaminants and could interact with the component of interest, resulting in slow purification of the molecule
- The inVitro protein concentration is low in serum-free media, resulting in low levels of contaminants. Hence, the target protein (lead molecule) is easier to purify with higher recovery through various methods such as centrifugation, HPLC, and mass spectrometry.
- Once the protein is produced in the serum-free media, it is tested for accuracy through various methods such as SDS PAGE, and mass spectrometry, which gives an idea whether the isolated protein is of interest
- Therefore, easier downstream processing of products post production from media is a major driver for the global serum-free media market
Increase in Demand for Various Recombinant Proteins and Types of Culture
- Presently, demand for pain relief devices is high due to arthritic pain, joint pain, knee pain, etc. Additionally, increase in incidence and prevalence of arthritis & joint diseases drive the demand of pain relief devices.
- According to CDC, one in every 30 adults in the U.S. suffers from pain problems, which is considered the eighth leading risk factor for disability and premature deaths. Medication and lifestyle changes are effective and affordable; however, the overall rate of pain relief control is suboptimal.
- Serum-free media is used in various types of suspension & adherent cultures for the production of immunological cells such as IL-2, IL-4, cytotoxic lymphocytes (CTLs), and monocytes, which are used in production of various vaccines
- Hence, increase in demand for recombinant proteins in various chronic diseases such as cancer is likely to propel the global serum-free media market
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Continuous Research & Development for Development of Novel Therapeutic Drugs
- Need of development of novel therapeutic drugs has increased due to various disadvantages associated with conventional and regular drugs due to their associated side effects and ineffectiveness in providing the required relief from the particular body indication
- Various research organizations and healthcare companies are involved in finding a better and modified version of existing drugs that not only can provide relief to various disease indications, but can also treat major diseases such as cancer
- Healthcare pharmaceutical & drug manufacturing companies are making significant investment in the research & development of novel therapeutic drugs, owing to increase in patient care and preference for these drugs
- Serum-free media is gaining popularity among major industry players. Hence, the serum-free media market is anticipated to expand at a high CAGR during the forecast period.
Serum-free Media Market: Competition Landscape
- This report profiles major players operating in the global serum-free media market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments
- The global serum-free media market is moderately fragmented with the presence of a large number of leading players and several small players in regional markets. Top players account for major share of the global serum-free media market.
- Prominent players operating in the global serum-free media market include
- Thermo Fisher Scientific
- Athena Environmental Sciences
- Pan Biotech
- Bichrom
- Irvine Scientific
- Biological Industries
- Sigma-Aldrich
- CellGenix
- HiMedia Laboratories
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