The Global RNA-interference Market Report by Global Insight Services is the single and trusted source of information for the RNA-interference Market. This report provides an analysis of the market impact of the latest market disruptions such as the Russian-Ukraine War and Covid-19. The report provides a qualitative analysis of the market using various frameworks such as Porters’ and PESTLE analysis. The report includes in-depth segmentation and market size data by category, product type, application, and region. The report also includes a comprehensive analysis of recent events such as key issues, trends and drivers, restraints and challenges, competitive landscape, and M&A activity in the market.
RNA interference (RNAi) is a process in which RNA molecules are used to inhibit gene expression or silence genes. RNAi occurs naturally in plants and animals and has been harnessed as a tool for biotechnology and medicine. RNAi is triggered by the presence of double-stranded RNA (dsRNA). When dsRNA is introduced into a cell, it is processed by an enzyme called Dicer into small interfering RNA (siRNA). SiRNA consists of two strands of RNA that are complementary to each other and bind to each other to form a double-stranded molecule. SiRNA then binds to a protein called RNA-induced silencing complex (RISC), which cleaves the complementary RNA strand. This process leads to the degradation of mRNA and the inhibition of gene expression.
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Key Trends
One trend is the increasing use of RNAi in vivo, in animal models of disease, and in agricultural settings. This is driven in part by the development of more effective delivery methods, such as lipid nanoparticles and viruses.
Another trend is the increasing use of RNAi for target validation, as it provides a quick and efficient way to assess the function of a gene of interest.
Finally, the increasing use of next-generation sequencing (NGS) to generate siRNA libraries is providing a powerful tool for functional genomics studies.
Key Drivers
The key drivers of the RNA-interference market are the increasing demand for RNA-based therapeutics, the rising prevalence of chronic diseases, and the growing investment in RNA-based research.
The demand for RNA-based therapeutics is increasing due to the growing understanding of the role of RNA in disease pathogenesis.
The prevalence of chronic diseases is rising due to the aging population and the growing prevalence of lifestyle diseases. Chronic diseases are often associated with aberrant gene expression, making RNA-based therapeutics an attractive treatment option.
The investment in RNA-based research is growing due to the increasing understanding of the role of RNA in disease pathogenesis and the potential of RNA-based therapeutics.
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Market Segments
The RNA-interference market is segmented by technology, application, and region. By technology, the market is classified into nanoparticle drugs, pulmonary drugs, and others. Based on the application, it is bifurcated into infectious disease, cardiology, and others. Region-wise, the market is segmented into North America, Europe, Asia Pacific, and the rest of the World.
Key Players
The RNA-interference market includes players such as Alnylam Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., CureVac AG, Dicerna Pharmaceuticals Inc., Gradalis Inc., Ionis Pharmaceuticals Inc, Merck & Co. Inc., Moderna Inc., Quark Pharmaceuticals Inc, Silence Therapeutics Plc, and others.
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