As per Global Insight services’ assessment, about 20+ prominent pharma and biotech giants are working on 20+ drugs in the Vitiligo – Drug Pipeline Landscape, 2023 globally. Vitiligo – Drug Pipeline Landscape, 2023″ report by Global Insight Services provides a comprehensive analysis of the ongoing clinical development activities and growth prospect.
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Vitiligo is a chronic disorder that causes patches of skin to lose pigment or color, when melanocytes are attacked and destroyed, causing the skin to turn a milky-white color. There are two types of vitiligo such as nonsegmental or generalized vitiligo and segmental vitiligo. Nonsegmental or generalized vitiligo happens when the white patches appear symmetrically on both sides of body, such as on both hands or both knees. Segmental vitiligo happens when the white patches are only on one segment or side of body, such as a leg, one side of the face, or arm.
The cause of vitiligo is unknown but researchers believe that vitiligo as an autoimmune disease. It’s is not clear exactly what causes these pigment cells to fail or die. Researchers suggest that it may be related to a disorder of the immune system (autoimmune condition), family history (heredity), a trigger event, such as stress, severe sunburn or skin trauma, such as contact with a chemical.
Symptoms of Vitiligo include patchy loss of skin color, premature hair graying, loss of color in the tissues that line the inside of the mouth and nose.
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Diagnosis of vitiligo is easy as the white patches are visible on the skin, but doctors use a Wood’s lamp, which shines ultraviolet (UV) light onto the skin to help differentiate from other skin conditions. Doctors may also suggest for other tests can include blood tests to check for other autoimmune diseases, an eye exam to check for uveitis, and a skin biopsy. Doctors can examine the tissue for the missing melanocytes seen in the depigmented skin of a person with vitiligo.
Treatments of Vitiligo can include medicines or medicated skin creams, use of light (phototherapy) to help return color to the skin, depigmentation and dermatologists may consider surgical techniques for long-standing segmental vitiligo.
There are many companies that are active in the development of vitiligo drugs. Some of these companies include AbbVie, Ahammune Biosciences Pvt. Ltd, Arcutis Biotherapeutics, Arrien Pharmaceuticals, Bristol-Myers Squibb etc.
Major pharmaceutical companies are involved in the development of potential drug candidates to improve the treatment of Vitiligo treatment such as Ritecitinib, Afamelanotide, VYN201, and others. Key players involved in the development of therapies to treat Vitiligo are AbbVie Inc, Pfizer, VYNE Therapeutics and others. One drug is under Phase III clinical trials and ten drugs are in Phase II clinical trials and some other drugs are under Phase I, IND/CTA filed, preclinical and discovery stages of development. In Oct 2022, Clinuvel Pharmaceuticals Ltd has enrolled first patient in a new clinical study (CUV104) evaluating the safety and efficacy of afamelanotide.
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Report Covers the Emerging Pipeline Products Under Different Phases of Clinical Development Like –
– Late-stage products (Phase III)
– Mid-stage products (Phase II)
– Early-stage product (Phase I)
– Pre-clinical and Discovery stage candidates
– Discontinued & Inactive candidates
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