The global male infertility market size is expected to reach USD 5.9 billion by 2030, according to a new report by Grand View Research, Inc. It is expected to expand at a CAGR of 4.9% from 2023 to 2030. Advancements in diagnostic tests and increasing infertility in males are some of the major factors driving the market for male infertility. In addition, lifestyle-associated diseases causing infertility, rising obesity, and the growing aging population are likely to boost market growth during the forecast period. In the U.S., one-third of infertility cases are due to female factors, one-third due to male factors, and the remaining one-third of the cases are unknown.
The COVID-19 pandemic had a severe impact on healthcare services. The diagnostic kits and critical medical supplies witnessed growing demand. On the other hand, most elective medical procedures dropped by around 50%. As only emergency medical procedures were allowed during the initial phase of the pandemic, the market observed a decline.
Male Infertility Market Report Highlights
- Based on test, DNA fragmentation technique dominated the market in 2022 and is estimated to witness significant growth over the forecast period due to the higher accuracy of the test
- The oxidative stress analysis test segment is gaining popularity due to the accurate determination of reactive oxygen species. In March 2018, Aytu BioScience, Inc. received registration from COFEPRIS in Mexico for MiOXSYS System, which is used for diagnosing male infertility
- Europe dominated the market in 2022 and is expected to maintain its lead during the forecast period due to high adoption of costlier treatment, strong diagnosis rate, and increased awareness
- Asia Pacific is projected to witness substantial growth over the forecast period owing to increasing investment by several clinics and pharmaceutical companies and growing healthcare expenditure
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Male infertility refers to the inability of a man to impregnate a fertile female partner. It is a medical condition characterized by the decreased or complete absence of sperm cells in the semen, or by sperm that are abnormal in shape, motility, or function. Male infertility can be caused by various factors, including:
- Low sperm count: A low concentration of sperm in the semen reduces the chances of fertilizing an egg.
- Abnormal sperm production or function: Genetic abnormalities, hormonal imbalances, or certain medical conditions can affect the production or function of sperm.
- Blockage or absence of the sperm ducts: Obstruction or absence of the tubes that carry sperm from the testes to the urethra can prevent sperm from reaching the ejaculate.
- Sexual problems: Erectile dysfunction, premature ejaculation, or other sexual difficulties may hinder the delivery of sperm during intercourse.
- Varicocele: This condition involves the enlargement of veins within the scrotum, leading to increased testicular temperature and impaired sperm production.
- Infections: Certain infections, such as sexually transmitted infections or urinary tract infections, can cause inflammation and damage to the reproductive system.
- Testicular injury or surgery: Trauma to the testicles or previous surgeries in the genital area can impact sperm production.
- Hormonal disorders: Imbalances in hormone levels, such as testosterone deficiency, can affect sperm production.
Diagnosis of male infertility involves a comprehensive evaluation, including a medical history review, physical examination, semen analysis, hormonal tests, genetic testing, and imaging studies. Treatments for male infertility depend on the underlying cause and may include medication, surgery, lifestyle changes, or assisted reproductive techniques such as in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). It’s important to note that male infertility does not necessarily indicate a complete inability to father a child. With advancements in reproductive medicine, many cases of male infertility can be successfully treated, allowing couples to achieve pregnancy and parenthood.
Latest Developments in Male Infertility Diagnostics & Treatment
Genetic testing techniques have improved, allowing for better identification of genetic abnormalities that may contribute to male infertility. This knowledge can help guide treatment decisions and provide couples with information about the likelihood of passing on genetic conditions to their offspring. Assisted reproductive technologies (ART), such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), continue to be widely used in cases of male infertility. These techniques involve the collection of sperm and the direct injection of a single sperm into an egg to facilitate fertilization. In cases where sperm is absent or cannot be ejaculated, sperm retrieval methods have shown advancements. Techniques like testicular sperm extraction (TESE) and microdissection TESE (micro-TESE) have improved the chances of finding viable sperm within the testicles, even in cases of severe male infertility. Cryopreservation techniques have improved, allowing for better preservation of sperm quality and viability. This is particularly beneficial for men undergoing treatments that may impact their fertility, such as cancer treatments or sterilizing procedures.
Research suggests that certain nutritional supplements and lifestyle modifications can positively impact sperm quality and fertility. For example, antioxidant supplements, such as vitamin C and vitamin E, have been investigated for their potential to improve sperm parameters. Researchers are exploring new medications and treatment options to address specific causes of male infertility. For instance, medications that target hormonal imbalances, improve sperm production, or treat conditions like varicocele are being studied and developed. Recognizing the emotional impact of male infertility, there is a growing emphasis on providing psychological support and counseling to couples undergoing fertility treatments. This can help them cope with the challenges, stress, and emotional strain associated with infertility.
DNA fragmentation technique emerged as the largest test segment in 2022 and is expected to maintain its lead during the forecast period. Increasing adoption in developed countries and high cost due to higher sensitivity and reliable analysis of sperm DNA integrity are the key factors driving the segment. The Assisted Reproductive Technology (ART) and varicocele surgery segment dominated the market for male infertility in 2022 due to its high success rate. Intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) are the most commonly used ARTs.
Partnerships and agreements among key manufacturers are expected to boost market growth in the coming years. For instance, in July 2019, Vitrolife entered into a collaboration with Prime Tech for the development and exclusive marketing of the Piezo technique for improved Intracytoplasmic Sperm Injection (ICSI) procedure in human IVF globally except Malaysia, Thailand, and Japan. Additionally, Vitrolife will initiate the regulatory approval procedures in various markets for the future commercialization of the technology.
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Male Infertility Market Insights By Region
Europe dominated the market, this is attributed to the availability of well-equipped and advanced fertility clinics, higher adoption of costlier treatment, better coverage for diagnosis and treatment, and high awareness level. Healthcare spending and the availability of well-established healthcare infrastructure are contributing significantly to the regional market growth. Asia Pacific is expected to witness the fastest growth. Emerging countries in the region, including India, China, and Singapore, have been witnessing strong economic growth. The Asian market is being driven by advancements in medical diagnostics as well as rising male infertility. The growing geriatric population, along with a rise in lifestyle-associated diseases, has resulted in an increase in the incidence rate of male infertility.
Competitive Analysis By Major Players
The market has been characterized by intense competition. Market players are expected to undertake strategies such as the development of innovative technologies for diagnosis and treatment, acquisitions, and partnerships or collaborations for the development and commercialization of products in order to remain competitive in the market. Furthermore, market players are availing certification from the regulatory agencies to strengthen their position in the market. The certification will provide recognition to its research work in all OECD member countries. Some prominent players in the global male infertility market include:
- Bayer Healthcare
- Andrology Solutions
- Aytu BioScience, Inc.
- Cadila Healthcare Ltd.
- Halotech DNA SL
- EMD Sereno, Inc.
Grand View Research has segmented the global male infertility market based on test, treatment, and region.
Research Methodology
We employ a comprehensive and iterative research methodology focused on minimizing deviance in order to provide the most accurate estimates and forecasts possible. We utilize a combination of bottom-up and top-down approaches for segmenting and estimating quantitative aspects of the market. Data is continuously filtered to ensure that only validated and authenticated sources are considered. In addition, data is also mined from a host of reports in our repository, as well as a number of reputed paid databases. Our market estimates and forecasts are derived through simulation models. A unique model is created and customized for each study. Gathered information for market dynamics, technology landscape, application development, and pricing trends are fed into the model and analyzed simultaneously.
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About Grand View Research
Grand View Research provides syndicated as well as customized research reports and consulting services on 46 industries across 25 major countries worldwide. This U.S. based market research and consulting company is registered in California and headquartered in San Francisco. Comprising over 425 analysts and consultants, the company adds 1200+ market research reports to its extensive database each year. Supported by an interactive market intelligence platform, the team at Grand View Research guides Fortune 500 companies and prominent academic institutes in comprehending the global and regional business environment and carefully identifying future opportunities.
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