The global microRNA market size is expected to reach USD 3.6 billion by 2028, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 19.8% from 2021 to 2028. Extensive research activities targeted towards exploring the potential functions of microRNA (miRNA) to design novel therapeutic solutions against different diseases is set to contribute to the adoption of miRNA instruments and consumables. These studies assist in understanding the mechanism of action of the signaling pathway, further integral to develop miRNA drug candidates.
microRNA Market Report Highlights
- The consumables segment accounted for the largest revenue share in 2020 and is expected to continue the trend in the forecast period owing to the use of PCR consumables for facilitating efficient RNA purification and multiple enzymatic steps
- The instruments segment is expected to witness gradual growth through 2021 to 2028 owing to its high costing and established penetration of PCR instruments for sequencing miRNA
- The profiling, localization, and quantification instruments segment dominated the market as it is an integral step that is witnessing an influx of technological advancement
- For instance, the development of bead-based miRNA profiling involves specific oligonucleotide probes which are later detected using flow cytometry
- The isolation and purification is expected to witness the fastest CAGR through 2021 to 2028 owing to the gaining popularity of studying gene expression for the identification of diseases
- The infectious disease segment generated the highest revenue in 2020, attributed to a steep increase in the adoption of miRNA isolation and purification kits across COVID-19 research and diagnostic workflows
- miRNA isolates are emerging as fundamental components to assess SARS-COV-2 infection characteristics
- They are involved in mechanisms such as alteration in epigenetic regulation, genomic instabilities, biogenesis machinery defects, and aberrant transcriptional control
- The cardiovascular disease segment is expected to witness a lucrative growth rate of 16.1% owing to the rising application of miRNAs as biomarkers for cardiovascular disorders such as myocardial infarction, atherosclerosis, and coronary artery disease
- The academic and government research institutes is estimated to hold the largest market share owing to the high adoption of research tools for studying miRNA in research institutes
- North America emerged as the highest revenue-generating region, capturing more than 45.0% revenue share in 2020 owing to its strong patent base for microRNA
- Research institutes in the region are conducting extensive research activities to find a link between miRNA and metabolic disorders
- For instance, in October 2020, a group of researchers from Regents of the University of California discovered that a microRNA is associated with metabolic diseases such as type 2 diabetes obesity, and insulin resistance
- Asia Pacific is expected to witness lucrative growth through 2021 to 2028 due to developing research infrastructure and involvement of local players in manufacturing kits and reagents
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MicroRNAs (miRNAs) are small non-coding RNA molecules that play a significant role in gene regulation. With lengths typically ranging from 18 to 25 nucleotides, miRNAs act as post-transcriptional regulators by binding to the messenger RNA (mRNA) molecules, thereby controlling their stability and translation into proteins. These tiny molecules are involved in numerous biological processes, including development, cell differentiation, immune response, and disease progression. By targeting specific mRNA sequences, miRNAs can either inhibit gene expression by degrading the mRNA or prevent its translation. Their ability to modulate multiple genes makes miRNAs powerful regulators, influencing various cellular functions and contributing to the complexity of gene regulatory networks. Understanding the roles of microRNAs has implications for unraveling fundamental biological mechanisms and potentially developing novel therapeutic interventions.
Researchers have been exploring the potential of miRNAs as biomarkers for diagnosing and prognosing various diseases. MiRNAs show promise in detecting cancer, cardiovascular disorders, neurodegenerative diseases, and more. Their stability in body fluids, such as blood and urine, makes them attractive candidates for non-invasive diagnostic tests. Efforts are underway to harness miRNAs as therapeutic targets. Scientists are developing strategies to modulate miRNA expression levels using antisense oligonucleotides, small molecule inhibitors, or viral vectors. This approach holds potential for treating diseases by either inhibiting miRNAs that contribute to pathology or supplementing miRNAs that act as tumor suppressors or regulators of other disease-related pathways.
The understanding of miRNA functions and their regulatory roles in various biological processes continues to expand. Researchers are conducting extensive studies to unravel the complex interactions between miRNAs and target genes, elucidating their impact on cellular processes, developmental pathways, and disease mechanisms. Advances in sequencing technologies and computational analysis have facilitated high-throughput profiling of miRNAs, leading to the identification of novel miRNAs and comprehensive cataloging of miRNA expression patterns. Additionally, the development of genome editing techniques, such as CRISPR-Cas9, is enabling precise manipulation of miRNA genes to study their functional significance. Effective delivery of miRNA-based therapeutics remains a challenge. Researchers are exploring various delivery platforms, including lipid nanoparticles, viral vectors, exosomes, and aptamers, to enhance the stability, specificity, and efficiency of miRNA delivery to target cells or tissues.
For instance, in June 2020, Munich researchers have discovered that a specific microRNA helps in preserving the integrity of the endothelium and hence reducing the risk of atherosclerosis. Robust funding in biotechnology companies offering miRNA therapeutics is further propelling the influx of miRNA companies. For instance, in February 2021, InteRNA Technologies received a funding of USD 22.46 million in a Series B funding round, led by AurorA Science, an Italian biotech investment company.
The funding will support the clinical evaluation of INT-1B3, its microRNA lead candidate for treating patients with advanced solid tumors. In addition, the grants will help in advancing proprietary preclinical drug candidates for addressing a variety of cancer indications. Moreover, microRNAs (miRNAs) can influence the expression of certain genes, which makes it a potential solution for developing future medicine. Additionally, researchers are exploring the role of micro-RNA in the management of SARS-COV-2 infection. Studies have indicated that miRNAs play a vital role in regulating innate and adaptive immune systems.
Furthermore, studies have shown that the expression of these miRNAs has a role in the host’s response against the coronavirus and other respiratory viruses. Several in-silico experimentations have displayed that miRNA interactions with SARS-CoV-1 cause upregulation of some miRNA such as miR-574-5p, miR-17, and miR-214; helping in the inhibition of viral replication. Hence, studying the changes in miRNA expressions using sequencing instruments can contribute to understanding the pathogenesis of such chronic respiratory infections.
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microRNA Market Insights By Region
North America dominated the microRNA (miRNA) market, growth in the region can be attributed to several factors such as the presence of key players, extensive R&D activities, and established research infrastructure for proteomics, genomics, and oncology. Companies in the region are receiving patent approvals for their miRNA biomarkers. Asia Pacific market for microRNA is expected to witness the fastest growth rate, growth can be primarily attributed to rapid advancement in genomic studies and the adoption of new tools for supporting research endeavors.
Competitive Analysis By Major Companies
Companies are expanding their patent portfolio for microRNA expression analysis. Some of the prominent players in the microRNA (miRNA) market include:
- Merck KGaA
- Thermo Fisher Scientific, Inc.
- Horizon Discovery Ltd.
- Synlogic
- QIAGEN
- GeneCopoeia, Inc.
- New England Biolabs
Segmented the global microRNA market on the basis of products, services, application, end-use, and region.
Research Methodology
We employ a comprehensive and iterative research methodology focused on minimizing deviance in order to provide the most accurate estimates and forecasts possible. We utilize a combination of bottom-up and top-down approaches for segmenting and estimating quantitative aspects of the market. Data is continuously filtered to ensure that only validated and authenticated sources are considered. In addition, data is also mined from a host of reports in our repository, as well as a number of reputed paid databases. Our market estimates and forecasts are derived through simulation models. A unique model is created and customized for each study. Gathered information for market dynamics, technology landscape, application development, and pricing trends are fed into the model and analyzed simultaneously.
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Grand View Research provides syndicated as well as customized research reports and consulting services on 46 industries across 25 major countries worldwide. This U.S. based market research and consulting company is registered in California and headquartered in San Francisco. Comprising over 425 analysts and consultants, the company adds 1200+ market research reports to its extensive database each year. Supported by an interactive market intelligence platform, the team at Grand View Research guides Fortune 500 companies and prominent academic institutes in comprehending the global and regional business environment and carefully identifying future opportunities.
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