Anticoagulants are essential medications used to prevent blood clot formation, mitigating potentially life-threatening conditions such as heart attacks and pulmonary embolisms. Reversal agents, including Eliquis and Xarelto reversal agents, serve to counteract uncontrolled bleeding in critical situations. Warfarin is reversed by Vitamin K, while Praxbind effectively reverses Pradaxa in emergency scenarios.
The escalating usage of reversal agents in combating life-threatening situations involving uncontrolled bleeding is expected to propel the global market for anticoagulant reversal drugs shortly. The surge in bleeding cases may result in unmet clinical needs due to the absence of specific reversal agents.
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Despite the presence of various coagulation factors in fresh frozen plasma (FFP) obtained from healthy blood donors, some plasma-derived clotting factors are rendered inactive. Recent advancements have introduced specialized products such as single clotting factor concentrates (e.g., factor VIII for hemophilia A and factor IX for hemophilia B) and prothrombin complex concentrate (PCC). PCC, derived from large plasma pools through ion-exchange chromatography from cryoprecipitate supernatant, consists of a blend of vitamin K-dependent factors and is of intermediate purity after the removal of antithrombin and factor XI.