Market Definition
The protein sequencing market size was USD 1,654.5 million in 2023 and is anticipated to reach USD 3,263.1 million in 2033, growing at a rate of 7.1% from 2024 to 2033.
Protein sequencing involves identifying the exact sequence of amino acids within a protein molecule, which is crucial for understanding its function and role in biological systems. This technique is fundamental in molecular biology and biochemistry, as it reveals the specific order of amino acids, which are the basic components of proteins, arranged in a linear sequence known as the protein’s primary structure. Understanding the primary structure helps to understand the genetic instructions of proteins, and it’s extremely important across many fields of science. Protein sequencing can be categorized into three main methods: investigating the N-terminus, exploring the C-terminus (limited methods, typically involving carboxypeptidases), and breaking down polypeptides into peptides.
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Market Outlook
The Rising Adoption Of Mass Spectrometry For Protein Sequencing
The adoption of mass spectrometry for protein sequencing represents a significant trend in the protein sequencing market, driven by several key factors. This include mass spectrometry offers unmatched sensitivity and accuracy in protein identification, enabling researchers to detect and characterize proteins even at low concentrations within complex biological samples. In studying diseases, it’s essential to detect even small changes in how proteins are made or altered because these changes can be really important for diagnosing and treating the illness..
Further, mass spectrometry allows for de novo protein sequencing, eliminating the reliance on existing genomic databases. This expands the scope of proteomic analysis, facilitating the discovery of novel proteins and post-translational modifications not cataloged in databases. Consequently, researchers can explore the full complexity of the proteome, uncovering previously unknown biological mechanisms and various physiological and pathological processes.
For instance., In March 2023, Bruker Corporation announced significant bioinformatics launches at the 19th US HUPO conference. These launches include the introduction of a novel de novo sequencing algorithm developed in collaboration with Rapid Novor Inc. The algorithm, called PaSER™ Novor, aims to enhance accuracy and speed for immunopeptidomics, particularly beneficial for analyzing small tumor biopsy samples.
Key Players Are Focusing Towards Manufacturing Integrated, Automated Sequencing Systems
The protein sequencing market is experiencing a notable trend towards the development of integrated and automated sequencing systems, driven by advancements in technology and a growing demand for efficient and accurate protein analysis. In March 2022, Thermo Fisher Scientific unveiled the CE-IVD marked Ion Torrent Genexus Dx Integrated Sequencer, a groundbreaking automated NGS platform designed for clinical laboratories. This system, delivering results within a single day, caters to both diagnostic testing and clinical research needs, streamlining processes and enhancing efficiency in protein sequencing. Moreover, in December 2022, Quantum-Si Incorporated introduced Platinum, the world’s first next-generation single-molecule protein sequencing platform. This innovation represents a significant leap forward in automated protein sequencing technology, offering enhanced precision and sensitivity in protein analysis.
Furthermore, various companies are leveraging partnerships and collaborations to enhance their sequencing capabilities. For instance, in January 2022, Illumina, Inc. announced a co-development agreement with SomaLogic to integrate the SomaScan Proteomics Assay onto Illumina’s high-throughput NGS platforms. This collaboration aims to accelerate the pace of proteomic research by combining Illumina’s scale and speed with SomaLogic’s innovative assay technology. Additionally, companies like Bruker Corporation are pushing the boundaries of sensitivity and performance in protein analysis. In June 2023, Bruker launched the timsTOF Ultra mass spectrometer, featuring transformative sensitivity enhancements on the 4D-Proteomics platform. This instrument incorporates advanced ionization and ion mobility technologies, facilitating comprehensive protein characterization with unparalleled accuracy and efficiency.
The Rise Of Personalized Medicine And The Growing Emphasis On Targeted Therapies Are Driving The Adoption Of Protein Sequencing
The emergence of personalized medicine is poised to significantly propel the growth of the protein sequencing market as personalized medicine becomes increasingly prevalent, there is a growing demand for precise and comprehensive analysis of an individual’s proteome. Protein sequencing plays a essential role in personalized medicine by enabling the precise analysis of an individual’s proteome, identifying specific protein biomarkers and mutations associated with their health or disease condition. This information guides the development of personalized diagnostics for early disease detection and monitoring, as well as the design of targeted therapies tailored to the unique biological characteristics of each patient, thereby maximizing treatment efficacy and minimizing adverse reactions.
Moreover, as the focus shifts towards targeted therapies designed to address the underlying molecular mechanisms of diseases, protein sequencing becomes even more essential. By explaining mutant protein sequences, protein sequencing provides essential understandings into the molecular basis of various diseases, guiding the design and development of precise therapeutic interventions. Furthermore, the increasing integration of genetic and proteomic data in personalized medicine further underlines the importance of protein sequencing.
Increasing Investment In Proteomic Research
Investments in proteomic research enable the development of advanced technologies and methodologies for studying proteins at a large scale. Proteomic research aims to understand the structure, function, and interactions of proteins within biological systems. This includes identifying and quantifying proteins, analyzing post-translational modifications, and elucidating protein-protein interactions. Additionally, an article from Forbes in 2021 highlights the potential of proteomics, stating that highly respected medical research facility the Baker Institute found proteomics provides 1000X more information than DNA.. This wealth of information provided by proteomics offers valuable insights into various biological processes, disease mechanisms, and potential drug targets. By investing in proteomic research, scientists can harness this wealth of information to enhance protein sequencing techniques.
Further the pharmaceutical and biotech companies, recognizing the potential of proteomics, have increased their investment in research and development in this area. Reports from companies like Novartis highlight successful proteomics programs that have produced new drug candidates and biomarkers, featuring the tangible returns on investment in proteomic research. Similarly, according to a report by Novo Holdings in 2023, a $40 million investment was made in Evosep, a bioscience company leading the standardization of proteomics for clinical use.
Market Restraints & Challenges
High Costs Associated with Protein Sequencing Technologies
One significant restraint in the global protein sequencing market is the high costs associated with protein sequencing technologies. Protein sequencing involves determining the precise order of amino acids within a protein molecule, which is essential for understanding its structure, function, and interactions. While protein sequencing plays a crucial role in various fields such as biotechnology, pharmaceuticals, and medical research, the expenses involved in acquiring and operating protein sequencing equipment, reagents, and software can be prohibitive for many organizations. The initial investment required to purchase protein sequencing equipment and setup laboratories can be substantial, posing a significant financial barrier to entry for smaller research institutions, academic laboratories, and startups. High-end protein sequencers, such as mass spectrometers and next-generation sequencing platforms, come with hefty price tags, often exceeding hundreds of thousands to millions of dollars. For instance, a high-end mass spectrometer capable of advanced protein analysis can cost over $500,000. Additionally, the ongoing costs associated with maintaining, calibrating, and upgrading these instruments further add to the financial burden.
In addition to equipment costs, there are significant operational expenses associated with protein sequencing, including reagents, consumables, and specialized software for data analysis and interpretation. High-quality reagents and consumables are essential for accurate and reliable protein sequencing results but can contribute substantially to overall project costs. Moreover, the complexity of protein sequencing workflows and data analysis requires skilled personnel, further increasing labor costs and resource requirements.
Volatility in Raw Materials Prices
The high costs associated with protein sequencing technologies limit the affordability and accessibility of protein sequencing services for researchers and organizations with limited financial resources. This disparity in access to protein sequencing capabilities hinders scientific progress and innovation, particularly in resource-constrained environment where research funding is limited. As a result, many promising research projects may be delayed or abandoned due to financial constraints, impeding advancements in areas such as drug discovery, biomarker identification, and personalized medicine. Furthermore, for businesses and institutions considering investments in protein sequencing technologies, there are inherent risks and uncertainties regarding the return on investment (ROI) and long-term sustainability. The substantial capital expenditure required for acquiring protein sequencing equipment represents a significant financial commitment, with no guarantee of immediate returns or profitability. Moreover, rapid technological advancements and evolving market dynamics pose risks of equipment obsolescence and depreciation, further complicating investment decisions.
Ultimately, while advancements in technology and economies of scale may lead to cost reductions over time, addressing the affordability and accessibility challenges of protein sequencing remains crucial for fostering widespread adoption and utilization of this critical analytical technique in scientific research and biomedical applications. Efforts to mitigate the financial barriers to entry, such as collaborative research initiatives, cost-sharing arrangements, and government funding support, are essential for overcoming this restraint and unlocking the full potential of protein sequencing in advancing scientific knowledge and improving human health.
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Research Objectives
• Estimates and forecast the overall market size for the total market, across product, service type, type, end-user, and region
• Detailed information and key takeaways on qualitative and quantitative trends, dynamics, business framework, competitive landscape, and company profiling
• Identify factors influencing market growth and challenges, opportunities, drivers and restraints
• Identify factors that could limit company participation in identified international markets to help properly calibrate market share expectations and growth rates
• Trace and evaluate key development strategies like acquisitions, product launches, mergers, collaborations, business expansions, agreements, partnerships, and R&D activities
• Thoroughly analyze smaller market segments strategically, focusing on their potential, individual patterns of growth, and impact on the overall market
• To thoroughly outline the competitive landscape within the market, including an assessment of business and corporate strategies, aimed at monitoring and dissecting competitive advancements.
• Identify the primary market participants, based on their business objectives, regional footprint, product offerings, and strategic initiatives
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Protein Sequencing Segmental Overview
The protein sequencing market is segmented into technology, application, end-user, components, protein type, platform, and region.
Key Players
The market includes players such as Agilent Technologies (USA), Thermo Fisher Scientific (USA), Shimadzu Corp (JPN), Waters Corp. (USA), Bio-Rad Laboratories (USA), Bruker Corporation (USA), Rapid Novor Inc. (CAN), Bioinformatics Solutions Inc., JEOL Ltd., Bio-Techne, Illumina, Inc., GenScript, Promega Corporation, Takara Bio Inc., New England Biolabs, Merck KGaA, PerkinElmer (Revvity), and Danaher Corporation.
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Research Scope
• Scope – Highlights, Trends, Insights. Attractiveness, Forecast
• Market Sizing – Product Type, End User, Offering Type, Technology, Region, Country, Others
• Market Dynamics – Market Segmentation, Demand and Supply, Bargaining Power of Buyers and Sellers, Drivers, Restraints, Opportunities, Threat Analysis, Impact Analysis, Porters 5 Forces, Ansoff Analysis, Supply Chain
• Business Framework – Case Studies, Regulatory Landscape, Pricing, Policies and Regulations, New Product Launches. M&As, Recent Developments
• Competitive Landscape – Market Share Analysis, Market Leaders, Emerging Players, Vendor Benchmarking, Developmental Strategy Benchmarking, PESTLE Analysis, Value Chain Analysis
• Company Profiles – Overview, Business Segments, Business Performance, Product Offering, Key Developmental Strategies, SWOT Analysis
• Market Size in 2023 – $ 1,654.5 Mn
• Market Size in 2031 – $ 3,263.1 Mn
• CAGR % – 7.1%
• Historic Period – 2017-2022
• Forecast Period – 2024-2033
• Base Year – 2023
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