Market Definition
The Long Read Sequencing Market encompasses advanced genomic sequencing technologies that enable the reading of long segments of DNA or RNA sequences. Unlike short-read sequencing, long-read sequencing provides greater accuracy in identifying complex genetic variations, structural variations, and repetitive regions in the genome. This market includes various platforms, instruments, reagents, and software used for sequencing and analyzing long reads in research, clinical, and industrial applications.
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Market Outlook
The Long Read Sequencing Market is anticipated to experience significant growth driven by the increasing demand for comprehensive and accurate genomic analysis. Long read sequencing technologies, such as those developed by Pacific Biosciences and Oxford Nanopore Technologies, are transforming the field of genomics by providing deeper insights into genetic variations and structural complexities that are often missed by short-read sequencing methods.
One of the primary drivers of market growth is the rising prevalence of genetic disorders and the need for precise genetic diagnosis. Long read sequencing offers superior capabilities in identifying structural variants, copy number variations, and other complex genetic alterations that are critical for diagnosing genetic diseases. This technology is particularly valuable in clinical settings, enabling personalized medicine approaches and improving patient outcomes.
Additionally, long read sequencing is playing a pivotal role in advancing cancer research. Its ability to accurately sequence challenging regions of the genome, such as telomeres, centromeres, and large structural variants, is crucial for understanding cancer genomics. This detailed genomic information aids in the development of targeted therapies and enhances the effectiveness of precision oncology.
The agricultural and environmental sectors are also benefiting from long read sequencing. In agriculture, this technology is used for crop and livestock genetic improvement, disease resistance research, and biodiversity studies. Environmental applications include microbial diversity analysis, metagenomics, and ecological monitoring. The comprehensive genomic data provided by long read sequencing is invaluable for advancing these fields.
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Research Objectives
- Estimates and forecast the overall market size for the total market, across product, service type, type, end-user, and region
- Detailed information and key takeaways on qualitative and quantitative trends, dynamics, business framework, competitive landscape, and company profiling
- Identify factors influencing market growth and challenges, opportunities, drivers and restraints
- Identify factors that could limit company participation in identified international markets to help properly calibrate market share expectations and growth rates
- Trace and evaluate key development strategies like acquisitions, product launches, mergers, collaborations, business expansions, agreements, partnerships, and R&D activities
- Thoroughly analyze smaller market segments strategically, focusing on their potential, individual patterns of growth, and impact on the overall market
- To thoroughly outline the competitive landscape within the market, including an assessment of business and corporate strategies, aimed at monitoring and dissecting competitive advancements.
- Identify the primary market participants, based on their business objectives, regional footprint, product offerings, and strategic initiatives
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Market Segmentation
The report analyses the global Long Read Sequencing Market based on technology, workflow, application, end-use, and region.
Global Long Read Sequencing Market by Technology
Based on technology, the Long Read Sequencing market is divided into Single-Molecule Real-Time Sequencing (SMRT), and Nanopore Sequencing. The single-molecule real-time (SMRT) sequencing segment is anticipated to grow at a significant rate of xx% from 2022-2030. This can be attributed to its longer read lengths and low systematic bias leading to achieving high consensus accuracy. Additionally, during sample preparation for SMRT, amplification is not necessary, thereby increasing its adoption in the research community.
On the other hand, nanopore sequencing technology is in its nascent stage. The technology is expected to grow considerably in the future and is expected to revolutionize the long-read sequencing market. Currently, Oxford Nanopore develops array chips that comprise protein nanopores that are fixed onto an electrically resistant polymer. This arrangement allows parallel runs of multiple experiments onto a single chip. The company is currently taking several efforts to enhance the utility of nanopore technology in the future.
Global Long Read Sequencing Market by Workflow
By workflow, the industry is categorised into Pre-sequencing, Sequencing, Data Analysis. The sequencing segment accounted for the largest revenue generation of USD xx million in 2022. This trend is anticipated to continue throughout the projection period. This is mostly due to the fact that it is one of the most crucial components of the workflow. Without using PCR amplification, long read technique enables library creation and real-time sequence analysis. This permits scientists to investigate the genetic material in its natural state and eliminates PCR-related bias from the genome. This makes it possible for long read technologies to directly identify methylation and other base changes.
A high number of algorithms and tools have been developed to carry out base calling, variant discovery, data handling, de novo assembly, and read mapping. Advancements in data analysis tools are expected to boost the market growth throughout the forecast period. Key players are expanding their market presence with the help of the development of novel tools and products. For instance, Pacific Biosciences launched Sequel Systems v9.0 Software in July 2020. The SMRT Analysis Software provides flexible command-line options, easy-to-use graphical user interface, and an extensive set of APIs.
Global Long Read Sequencing Market by Application
Based on application, the industry is categorized into Identification & fine mapping of structural variation, Tandem Repeat Sequencing, Pseudogene discrimination, Cancer, and Others. The cancer segment dominated the long-read sequencing market in 2021. SMRT sequencing has been found to be useful in cancer research as it provides access to a complete size spectrum of genetic variation in whole genomes, transcripts, and genes. The exceptionally long reads of SMRT sequencing allow researchers to discover the hidden biology of cancer samples by resolving isoform diversity, alternative splice sites, gene fusions, and retained introns.
Similarly, advancements in the field of nanopore sequencing have revealed novel areas in the field of cancer biology. In April 2019, researchers from Oxford University collaborated with Ontario Institute for Cancer Research to use nanopore sequencing to understand the mechanisms and patterns of DNA replication. The initiative was undertaken to understand the mechanism of DNA replication in cancerous cells. Researchers from both institutions co-developed D-NAscent, a computational tool and a sophisticated laboratory protocol, which allows the study and detection of DNA replication in cancerous cells.
Global Long Read Sequencing Market by End-use
Based on end-use, the Long Read Sequencing market is divided into Academic Research, Clinical Research, Hospitals & Clinics, Pharma & Biotech Entities, and Other. In 2022, academic research captured a significant market share. This is owing to the presence of numerous biotechnology research centers that study molecular biology and genome sequencing techniques. Along with this, academic workshops, on-site bioinformatics courses provided by universities, and the rising use of sequence analysis approaches in research are anticipated to strengthen the academic research sector.
On the other hand, the clinical research market is likely to be driven by the demand for cutting-edge technology for clinical diagnostics. Long read sequencing technology’s potential clinical applications in clinical settings are anticipated to drive category growth. In order to deploy the approach in clinical practice with a streamlined laboratory workflow, market participants are actively working to address the current problems connected with the implementation of technology. In the upcoming years, it is anticipated that technology for chronic disease prognosis would be widely adopted in hospitals and clinics. Growth is anticipated to be fueled by ongoing studies into the use of this technology in various medical states.
Major Players
Market players are focusing on strategic collaborations to enhance their product offerings. Some prominent participants in the global market are Long Read Sequencing market include Oxford Nanopore Technologies Limited; Pacific Biosciences of California, Inc.; Quantapore, Inc.; Stratos Genomics, Inc.; MicrobesNG; Institute of Integrative Biology of the Cell (I2BC); BaseClear B.V.; Future Genomics Technologies B.V.; Garvan Institute of Medical Research; Genome Transcriptome Facility of Bordeaux; NextOmics; and Takara Bio, Inc. among others.
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Research Scope
- Scope – Highlights, Trends, Insights. Attractiveness, Forecast
- Market Sizing – Product Type, End User, Offering Type, Technology, Region, Country, Others
- Market Dynamics – Market Segmentation, Demand and Supply, Bargaining Power of Buyers and Sellers, Drivers, Restraints, Opportunities, Threat Analysis, Impact Analysis, Porters 5 Forces, Ansoff Analysis, Supply Chain
- Business Framework – Case Studies, Regulatory Landscape, Pricing, Policies and Regulations, New Product Launches. M&As, Recent Developments
- Competitive Landscape – Market Share Analysis, Market Leaders, Emerging Players, Vendor Benchmarking, Developmental Strategy Benchmarking, PESTLE Analysis, Value Chain Analysis
- Company Profiles – Overview, Business Segments, Business Performance, Product Offering, Key Developmental Strategies, SWOT Analysis
- Market Size in 2022 – $1.5 Billion
- Market Size in 2032 – $6.0 Billion
- CAGR % – 14.8%
- Historic Period – 2016 – 2021
- Forecast Period – 2023 – 2032
- Base Year – 2022
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