Global acute repetitive seizures also called seizure clusters, are common phenomena in patients with epilepsy. Epilepsy is the most common neurological disease with 70 million people in the world suffering from it and around 4.6 million developing the condition each year. The epilepsy report seizures which occur in close succession; these are term as seizure clusters (SC), acute repetitive seizures (ARS), or crescendo seizures. Acute repetitive seizures are associated with a failure to inhibit the epileptic discharge in the brain. Acute repetitive seizures are episodes of increased seizure activity in which two or more seizures occur in 24 hours. These seizures occur one after the other typically during the recovery period between each seizure and are different from a person’s seizure pattern. If acute repetitive seizures remain untreated, they may progress to status epileptus is a serious condition in which seizures last for more than five minutes to two days. Some of the triggers due to which acute repetitive syndrome occurs are sleep deprivation, stress, skipping epilepsy medication, and using alcohol and recreational drugs.
The treatment of acute repetitive syndrome must be individualized. It must depend on the type, frequency, severity, and duration of a duration of seizures in the cluster, and whether episodes have been known to progress to prolonged seizures or status epileptics. The treatment should be commensurate with the severity of the cluster, it should depend on how close the seizures close to each other. A significant reduction in acute repetitive seizure has been reported in patients with refractory epilepsy who had the Vagus Nerve Stimulation device implanted. Each patient needs to have a seizure action plan that includes rescue therapy for seizure clusters, detailing when to administer treatment and what medication and dose to administer. The patient and caregivers have to be counseled and trained on the administration of rescue treatment. Early treatment outside the hospital reduces morbidity and mortality of seizure clusters, reduces the cost of treatment, and improves the quality of life for patients and their families and caregivers.
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Global Acute Repetitive Seizures Market – Competitive Landscape
The global acute repetitive seizure market is characterized by a dynamic interplay of pharmaceutical companies, medical device manufacturers, and healthcare providers dedicated to providing urgent needs for patients experiencing acute coronary events. The landscape is marked by continuous innovation, research, and rapid response aimed at improving outcomes for patients in critical need.
Some of the Key Players in the Global Acute Repetitive Market Include –
- Grupo Ferrer International S.A. (ALEXZA)
- Valeant Pharmaceutical
- North America LLC
- Neurelis
- USB S.A.
- Novartis
- Sanofi S.A.
- Teva Pharmaceutical Industries
- Sage Therapeutics
Global Acute Repetitive Seizures Market – Growth Drivers
The rising prevalence of epilepsy and other conditions associated with acute repetitive seizures, possibly due to factors like genetic predisposition and environmental triggers, drives the demand for better treatment options. According to the National Centers for Biotechnology Information (NCBI), the prevalence rate of acute repetitive seizures is 10% to 50% Continuous research and development efforts in the pharmaceutical sector lead to the discovery of more effective and better-tolerated antiepileptic medications, improving seizure control and patient quality of life. Patient and caregiver awareness about epilepsy and available treatment options lead to early diagnosis and reducing the impact of recurrent seizures. Supportive policies and government programs that promote epilepsy awareness, research, and improved healthcare access to improved market growth. Economic development in emerging markets can lead to greater access to healthcare services.
Global Acute Repetitive Seizure Market – Restraints
The high costs of acute repetitive seizure medications and medical devices can be significant access, particularly in regions with limited healthcare resources. According to the National Center for Biotechnology Information (NCBI), healthcare spending for seizure and epilepsy has recently represented an incremental cost of USD 24.5 billion annually. Medications and medical devices used to manage seizures can have side effects or safety issues, which may affect patient adherence and treatment outcomes. Some patients with acute repetitive seizures do not respond well to available treatments, leaving them with uncontrolled seizures and a reduced quality of life. Diagnosing the specific cause of acute repetitive seizures can be challenging, leading to delays in appropriate treatment. Developing and gaining regulatory approval for new antiepileptic medications and medical devices can be a lengthy and costly process, which can hamper the innovations.
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Global Acute Repetitive Seizure Market – Opportunities
Expanding access to epilepsy care in different unreserved regions and emerging markets offers opportunities for market growth. Developing collaborative care models that involve neurologists, primary care physicians, and other healthcare professionals can lead to more comprehensive and effective patient care. Research and development for rare and treatment-resistant epilepsies present opportunities for unmet medical needs in this patient population. Opportunities exist for developing and promoting preventive measures that reduce the risk of acute repetitive seizures.
Global Acute Repetitive Seizure Market – Geographical Insight
The global market of acute repetitive seizures is segmented into the regions of North America, Latin America, Europe, Asia-Pacific, Middle East, and Africa. North America is the largest growing market including the United States and Canada for acute repetitive seizures due to the benefits of advanced healthcare infrastructure, high-level awareness, and access to cutting-edge treatments. Europe has a well-established market for acute repetitive seizure management, with countries like the United Kingdom, Germany, and France at the forefront. In the Asia-Pacific region including the countries like Japan, South Korea, and Australia, there’s a growing awareness of epilepsy.
Global Acute Repetitive Seizures Market – Key Development
- Neurelis Inc. in 2023, announced the long-term phase 3 safety study of VALTOCO® (diazepam nasal spray) in the pediatric population for rescue medication on seizure timing.
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