The downstream processing industry was estimated to be worth US$6.7 billion globally in 2019. It is anticipated to grow quickly between 2020 and 2030. Following the fermentation process, several steps in the downstream processing process are carried out to recover and purify the desired products. It includes product isolation, purification, polishing, and elimination of insoluble materials. The demand for COVID-19 vaccines, the introduction of new products and solutions for microbial fermentation, the development of new biotherapeutics with smaller molecular weight, and the rise in incidence rates of chronic disorders with significant unmet medical needs are driving the global downstream processing market.
All biological platforms for the manufacture of biopharmaceutical proteins produce an initially turbid extract that must be clarified to avoid fouling-sensitive media such as chromatography resins. Clarification is more challenging if the feed stream contains large amounts of dispersed particles because these rapidly clog the filter media typically used to remove suspended solids. Charged polymers (flocculants) can increase the apparent size of the dispersed particles by aggregation, facilitating the separation of solids and liquids, and thus reducing process costs. However, many different factors can affect the behavior of flocculants, including the pH and conductivity of the medium, the size and charge distribution of the particulates, and the charge density and molecular mass of the polymer. Importantly, these properties can also affect the recovery of the target protein and the overall safety profile of the process.
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Global Downstream Processing Market-Competitive Insights
On 14 June 2022, Merck collaborated with Agilent Technologies to reduce the industry gap in process analytical technologies (PAT) for downstream processing. Under the collaboration, the companies combine Merck’s bioprocess portfolio with Agilent Technologies’ advanced analytical products to extend real-time monitoring and automated process control of critical process parameters (CPPs) and critical quality attributes (CQAs) in downstream processing (DSP).
On May 19, 2022, Sartorius began focusing on the growth of its global production capacity with the expansion of its manufacturing site in Tunisia.
On March 19, 2020, Eppendorf AG acquired Koki Holdings Co., Ltd. This acquisition enabled the company to enhance the centrifuge business and consolidate its market position.
Some of the Key Players in the Global Downstream Processing Market Includes –
- BoehringerIngelheim
- Danaher Corporation
- Sartorius Stedium Biotech S.A
- GE Healthcare
- Merck Millipore
- Eppendorf AG
- 3M Company
- Thermo Fisher Scientific Inc
- Finesse Solutions Inc
- Lonza Group
Global Downstream Processing Market – Growth drivers
The adoption of both upstream and downstream processing equipment is expected to be driven by the development of new biotherapeutics with lower molecular weights. Shortly, it is anticipated that the use of these systems for the synthesis of tiny peptide fragments, recombinant proteins, antibody fragments, and components of antibody-drug conjugates (ADCs) will rise. The demand for more adaptable small-to-medium capacity production is expected to increase with the introduction of tailored medications and a diversified product range. To generate these biotherapeutics, biopharmaceutical producers can use single-use, small-scale systems with a capacity of 100-500 liters instead of massive fermenters. Therefore, it is anticipated that throughout the projected period, the development of new biotherapeutics with lower molecular weight will increase the worldwide downstream processing market.
Global Downstream Processing Market -Restraints
The cost of separation and purification often makes up more than half of the overall process cost. To build a cost-effective bioprocess, the downstream process is carefully examined. Numerous separation and purification procedures have been combined to achieve the requisite degree of purity, which has increased the cost of the downstream process. Even though the efficiency of each stage is satisfactory, the system’s extensive steps result in an increase in equipment costs as well as a reduction in the process’ overall separation efficiency. The monitoring and control of bioprocesses, such as downstream processing, have become more complex as a result of production process advancements, particularly in the biopharmaceutical and nutraceutical industries, and the limitations of some modern and some classical control system techniques are now becoming evident. The above-mentioned factors pose a restrictive impact on the downstream processing industry and call for prompt attention toward optimization techniques for a smooth process flow.
Global Downstream Processing Market -Opportunities
It is most likely the development of new biotherapeutics with lower molecular weights that are driving the use of both upstream and downstream processing technology. Shortly, these techniques will likely be applied more often to the production of small peptide fragments, recombinant proteins, antibody fragments, and antibody-drug conjugate (ADC) components. It is projected that the development of innovative biotherapeutics with a reduced molecular weight will drive the worldwide downstream processing market by generating lucrative prospects.
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Global Downstream Processing Market-Geographical Insights
The Global Downstream Processing Market is segmented by geography into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. North America dominated the market and accounted for the greatest revenue share of more than 35 percent in 2021. In addition, the region has seen large collaboration activities with healthcare companies that are investing heavily in the research and development of biopharmaceuticals and vaccines. These activities have taken place. In addition, the most important companies that are currently active in the market are increasing their influence in this area. For example, Thermo Fisher Scientific Inc. only recently made public its intention to increase the size of its clinical research facilities in the city of Richmond, Virginia, by investing $97 million. From 2020 to 2030, the Asia Pacific downstream processing industry is projected to grow at a rapid compound annual growth rate (CAGR). The biopharmaceutical industry in China and India is growing quickly, which has led to the market’s expansion in the area. Leading companies are also concentrating on establishing their presence in new regions.
Global Downstream Processing Market– Key Development
- On April 20, 2022, Thermo Fisher Scientific opened a bioprocessing manufacturing site in Ogden, Utah, for the development of biologics and vaccines.
- On May 19, 2022, Sartorius began focusing on the growth of its global production capacity with the expansion of its manufacturing site in Tunisia.
- On June 13, 2022, Bio-Rad introduced the CHT™ prepacked Foresight Pro Columns to serve downstream process-scale chromatography applications throughout all stages of biological drug research and manufacture.