Cryopreservation or cryo conservation is a process where biological material cells, tissues, or organs are frozen to preserve the material for an extended period. At low temperatures typically -80 to -196 degrees Celsius any cell metabolism that might cause damage to the biological material in question is effectively stopped. Cryopreservation is an effective way to transport biological samples over long distances, store samples for prolonged periods, and create a bank of samples for users. Molecules referred to as cryoprotective agents, are added to reduce the osmotic shock and physical stresses cells undergo in the freezing processes. Some cryoprotective agents used in research are inspired by plants and animals in nature that have unique cold tolerance to survive harsh winters including trees, wood frogs, and tardigrades.
Generally, is easier for thin samples and suspended cells, because these can be cooled more quickly and so require lesser doses of toxic cryoprotectants. Therefore, cryopreservation of human livers and hearts for storage and transplant is still impractical. The main technique to prevent cryopreservation damage is a well-established combination of controlled rate and slow freezing and a newer flash-freezing process known as vitrification. Significant improvements in understanding of the cryopreservation principles and techniques for long-term storage and cryobanking of the cell. The success of any cryopreservation protocol is dictated by the careful selection of new common variables.
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Global Cellular Cryopreservation Market – Competitive Landscape
On December 7, 2023, the cell cryopreservation market surged with advances in biotechnology and research applications. On December 22, 2021, X-Therma closed an Oversubscribed USD 13 million series A financing led by LORE AG. On August 30, 2021, Cryo-Cell International announced uplifting to the Nasdaq capital market. On December 1, 2020, BioLife Solutions & Casdin Capital innovation accelerator announced a new investment in cell therapy bioproduction tools.
Some of the Key Players in the Global Cellular Cryopreservation Market Include –
- Thermo Fisher Scientific Inc.
- Merck KGaA
- Sartorius AG
- PromoCell GmbH
- Lonza
- HiMedia Laboratorieses
- Creative Biolabs
- Corning Incorporated
- GE Healthcare
- Bio-Rad Laboratories
Global Cellular Cryopreservation Market – Growth Drivers
The growing prevalence of infertility issues and the rising demand for ART procedures, such as in vitro fertilization, drive the need for cellular cryopreservation methods to preserve reproductive cells. According to the World Health Organization, the prevalence of infertility issues was 17.8% in income countries and 16.5% in low-income and middle-income countries. Cellular cryopreservation plays a crucial role in regenerative medicine by preserving stem cells, tissues, and other biological material for potential future therapeutic applications, contributing to the market’s growth. Ongoing technological advancements in biobanking and bio-preservation techniques enhance the efficiency and success rates of cellular cryopreservation, attracting increased adoption across research institutions and healthcare facilities. Continued investment in R&D activities focused on improving cryopreservation methods and developing novel solutions for long-term cell storage contribute to the expansion of the cellular cryopreservation market. Increasing awareness among healthcare professionals and the general public about the benefits of cryopreservation in preserving biological materials, including gametes and embryos, fosters acceptance and drives market growth. The establishment of private stem cell banks for personalized health management and therapeutics use amplifies the demand for cellular cryopreservation services, especially among individuals seeking to preserve their stem cells. Favorable regulatory frameworks and guidelines related to the storage and use of cryopreserved cells create a conducive environment for market expansion, encouraging more players to enter the space.
Global Cellular Cryopreservation Market – Restraints
The cellular cryopreservation market faces ethical and legal challenges in the storage and use of reproductive cells, embryos, and tissues, leading to regulatory complexities and potential public resistance. The substantial high cost associated with cellular cryopreservation procedures including storage, can be a significant barrier, limiting accessibility for certain individuals and hindering widespread adoption of these services. The estimated cost of cryopreservation ranges from USD 28,000 to USD 200,000. Lack of awareness and education about the benefits of cellular cryopreservation in developing regions hampers market growth, as potential users may not fully understand the importance of preserving biological material for future use. Despite advancements, certain technological limitations, such as the potential for cell damage during freezing and thawing processes, still exist, impacting the overall efficacy and success rates of cellular cryopreservation. Maintaining consistent quality control and standardization across various cryopreservation facilitates can be challenging, potentially leading to variations in outcomes and raising concerns about the reliability of stored biological materials. Inadequate or limited reimbursement policies for cellular cryopreservation services in some healthcare systems can impede market growth, as potential users may be deterred by the lack of financial support. Cultural and religious beliefs may influence the acceptance of cellular cryopreservation, especially in matters related to reproductive cells, leading to varying levels of acceptance and adoption across different populations.
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Global Cellular Cryopreservation Market – Opportunities
The increasing trend toward personalized medicine creates opportunities for cellular cryopreservation, as preserved cells can be utilized for personalized treatments, including cell-based therapies tailored to an individual’s unique genetic makeup. Cellular cryopreservation facilitates the storage of cell lines crucial for drug discovery and development, presenting opportunities for partnerships between cryopreservation service providers and pharmaceutical companies. The rising awareness of the therapeutic potential of cord blood banking services offers a significant growth avenue for the cellular cryopreservation market. The integration of AI in cryopreservation processes and data analysis enhances efficiency and decision-making, providing opportunities for innovative solutions and further automation within the cellular cryopreservation market.
Global Cellular Cryopreservation Market – Geographical Insight
The market for global cellular cryopreservation is segmented into regions such as North America, Latin America, Europe, Asia-Pacific, the Middle East & Africa. North America is the largest market for global cellular cryopreservation due to advanced healthcare infrastructure and a propensity for adopting cutting-edge technologies that contribute to the significant market share of cellular cryopreservation in North America. European countries actively participate in biobanking initiatives, promoting the storage of biological materials and driving the demand for cellular cryopreservation services. The Asia-Pacific region is experiencing a surge in fertility treatments, leading to a growing demand for cellular cryopreservation services, especially in countries with rapidly developing healthcare infrastructure.
Global Cellular Cryopreservation Market – Key Development
- On November 17, 2023, Charles River Laboratories launched CliniPrime Cryopreserved Leukopaks for cell therapy development and manufacturing.
- On October 11, 2023, OrganBio, the contract technology development and manufacturing organization specializing in solutions for cell and immunotherapy development, announced the launch of cell processing and cryopreservation services.
- On January 28, 2022, Cryopart and Cell Matters team up on cryopreservation services.